Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease

Multiple sclerosis (MS) is a neuroinflammatory, demyelinating disease of the CNS. Fibrinogen deposition at sites of blood–brain barrier breakdown is a prominent feature of neuroinflammatory disease and contributes to disease severity. Plasminogen, the primary fibrinolytic enzyme, also modifies infla...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Shaw, Maureen A., Gao, Zhen, McElhinney, Kathryn E., Thornton, Sherry, Flick, Matthew J., Lane, Adam, Degen, Jay L., Ryu, Jae Kyu, Akassoglou, Katerina, Mullins, Eric S.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394895/
https://ncbi.nlm.nih.gov/pubmed/28275164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2932-15.2017
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