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Structural and functional analysis of the human POT1-TPP1 telomeric complex
POT1 and TPP1 are part of the shelterin complex and are essential for telomere length regulation and maintenance. Naturally occurring mutations of the telomeric POT1–TPP1 complex are implicated in familial glioma, melanoma and chronic lymphocytic leukaemia. Here we report the atomic structure of the...
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| Published in: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5394233/ https://ncbi.nlm.nih.gov/pubmed/28393830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14928 |
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