Structural and functional analysis of the human POT1-TPP1 telomeric complex

POT1 and TPP1 are part of the shelterin complex and are essential for telomere length regulation and maintenance. Naturally occurring mutations of the telomeric POT1–TPP1 complex are implicated in familial glioma, melanoma and chronic lymphocytic leukaemia. Here we report the atomic structure of the...

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Published in:Nat Commun
Main Authors: Rice, Cory, Shastrula, Prashanth Krishna, Kossenkov, Andrew V., Hills, Robert, Baird, Duncan M., Showe, Louise C., Doukov, Tzanko, Janicki, Susan, Skordalakes, Emmanuel
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394233/
https://ncbi.nlm.nih.gov/pubmed/28393830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14928
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