Regulation of Thalamic and Cortical Network Synchrony by Scn8a

Voltage-gated sodium channel (VGSC) mutations cause severe epilepsies marked by intermittent, pathological hypersynchronous brain states. Here we present two mechanisms that help to explain how mutations in one VGSC gene, Scn8a, contribute to two distinct seizure phenotypes: (1) hypoexcitation of co...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Makinson, Christopher D., Tanaka, Brian S., Sorokin, Jordan M., Wong, Jennifer C., Christian, Catherine A., Goldin, Alan L., Escayg, Andrew, Huguenard, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393918/
https://ncbi.nlm.nih.gov/pubmed/28238546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.01.031
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