The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3’-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. Thus, small molecules that interfere with the HuR-ARE interaction could...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Kaur, Kawaljit, Wu, Xiaoqing, Fields, James K., Johnson, David K., Lan, Lan, Pratt, Miranda, Somoza, Amber D., Wang, Clay C. C., Karanicolas, John, Oakley, Berl R., Xu, Liang, De Guzman, Roberto N.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393604/
https://ncbi.nlm.nih.gov/pubmed/28414767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175471
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