The BET protein BRD2 cooperates with CTCF to enforce transcriptional and architectural boundaries

BET (bromodomain and extraterminal motif) proteins are pharmacologic targets for the treatment of diverse diseases, yet the roles of individual BET family members remain unclear. We find that BRD2 but not BRD4 colocalizes with the architectural/insulator protein CCCTC-binding factor (CTCF) genome-wi...

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Publicat a:Mol Cell
Autors principals: Hsu, Sarah C., Gilgenast, Thomas G., Bartman, Caroline R., Edwards, Christopher R., Stonestrom, Aaron J., Huang, Peng, Emerson, Daniel J., Evans, Perry, Werner, Michael T., Keller, Cheryl A., Giardine, Belinda, Hardison, Ross C., Raj, Arjun, Phillips-Cremins, Jennifer E., Blobel, Gerd A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393350/
https://ncbi.nlm.nih.gov/pubmed/28388437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.02.027
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