The BET protein BRD2 cooperates with CTCF to enforce transcriptional and architectural boundaries

BET (bromodomain and extraterminal motif) proteins are pharmacologic targets for the treatment of diverse diseases, yet the roles of individual BET family members remain unclear. We find that BRD2 but not BRD4 colocalizes with the architectural/insulator protein CCCTC-binding factor (CTCF) genome-wi...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Hsu, Sarah C., Gilgenast, Thomas G., Bartman, Caroline R., Edwards, Christopher R., Stonestrom, Aaron J., Huang, Peng, Emerson, Daniel J., Evans, Perry, Werner, Michael T., Keller, Cheryl A., Giardine, Belinda, Hardison, Ross C., Raj, Arjun, Phillips-Cremins, Jennifer E., Blobel, Gerd A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393350/
https://ncbi.nlm.nih.gov/pubmed/28388437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.02.027
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