Epitope Recognition in HLA-DR3 Transgenic Mice Immunized to TSH-R Protein or Peptides

Development of Graves' disease is related to HLA-DR3. The extracellular domain (ECD) of human TSH receptor (hTSH-R) is a crucial antigen in Graves' disease. hTSH-R peptide 37 (amino acids 78–94) is an important immunogenic peptide in DR3 transgenic mice immunized to hTSH-R. This study exam...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Inaba, Hidefumi, Moise, Leonard, Martin, William, De Groot, Anne S., Desrosiers, Joe, Tassone, Ryan, Buchman, George, Akamizu, Takashi, De Groot, Leslie J.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Thyroid-TRH-TSH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393327/
https://ncbi.nlm.nih.gov/pubmed/23592747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1033
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