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Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo
T cell-dependent development of anti-factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anch...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288193/ https://ncbi.nlm.nih.gov/pubmed/22222093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2011.11.010 |
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