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Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice

Recent studies have reported spread of pathogenic proteins in the mammalian nervous system, but whether nonpathogenic ones spread is unknown. We initially investigated whether spread of a mutant amyotrophic lateral sclerosis-associated cytosolic superoxide dismutase 1 (SOD1) protein between motor ne...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Thomas, Eleanor V., Fenton, Wayne A., McGrath, James, Horwich, Arthur L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393223/
https://ncbi.nlm.nih.gov/pubmed/28348221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701465114
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