Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

Humans with ALS and transgenic rodents expressing ALS-associated superoxide dismutase (SOD1) mutations develop spontaneous blood–spinal cord barrier (BSCB) breakdown, causing microvascular spinal-cord lesions. The role of BSCB breakdown in ALS disease pathogenesis in humans and mice remains, however...

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Detalhes bibliográficos
Main Authors: Winkler, Ethan A., Sengillo, Jesse D., Sagare, Abhay P., Zhao, Zhen, Ma, Qingyi, Zuniga, Edward, Wang, Yaoming, Zhong, Zhihui, Sullivan, John S., Griffin, John H., Cleveland, Don W., Zlokovic, Berislav V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964055/
https://ncbi.nlm.nih.gov/pubmed/24591593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401595111
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