Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

Humans with ALS and transgenic rodents expressing ALS-associated superoxide dismutase (SOD1) mutations develop spontaneous blood–spinal cord barrier (BSCB) breakdown, causing microvascular spinal-cord lesions. The role of BSCB breakdown in ALS disease pathogenesis in humans and mice remains, however...

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Autors principals: Winkler, Ethan A., Sengillo, Jesse D., Sagare, Abhay P., Zhao, Zhen, Ma, Qingyi, Zuniga, Edward, Wang, Yaoming, Zhong, Zhihui, Sullivan, John S., Griffin, John H., Cleveland, Don W., Zlokovic, Berislav V.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964055/
https://ncbi.nlm.nih.gov/pubmed/24591593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401595111
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