ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease

Proteolytic processing of amyloid precursor protein (APP) C-terminal fragments (CTFs) by γ-secretase underlies the pathogenesis of Alzheimer’s disease (AD). An RNA interference screen using APP-CTF [99-residue CTF (C99)]- and Notch-specific γ-secretase interaction assays identified a unique ErbB2-ce...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Bo-Jeng, Her, Guor Mour, Hu, Ming-Kuan, Chen, Yun-Wen, Tung, Ying-Tsen, Wu, Pei-Yi, Hsu, Wen-Ming, Lee, Hsinyu, Jin, Lee-Way, Hwang, Sheng-Ping L., Chen, Rita P.-Y., Huang, Chang-Jen, Liao, Yung-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393216/
https://ncbi.nlm.nih.gov/pubmed/28351972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618804114
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