Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A

Endothelial cells (ECs) not only are important for oxygen delivery but also act as a paracrine source for signals that determine the balance between tissue regeneration and fibrosis. Here we show that genetic inactivation of flow-induced transcription factor Krüppel-like factor 2 (KLF2) in ECs resul...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Manavski, Yosif, Abel, Tobias, Hu, Junhao, Kleinlützum, Dina, Buchholz, Christian J., Belz, Christina, Augustin, Hellmut G., Boon, Reinier A., Dimmeler, Stefanie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393189/
https://ncbi.nlm.nih.gov/pubmed/28348240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613392114
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