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The Blood-Brain Barrier: Bottleneck in Brain Drug Development

Summary: The blood-brain barrier (BBB) is formed by the brain capillary endothelium and excludes from the brain ∼100% of large-molecule neurotherapeutics and more than 98% of all small-molecule drugs. Despite the importance of the BBB to the neurotherapeutics mission, the BBB receives insufficient a...

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Hlavní autor: Pardridge, William M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Experimental NeuroTherapeutics, Inc. 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC539316/
https://ncbi.nlm.nih.gov/pubmed/15717053
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