Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance

Solid tumours have oxygen gradients and areas of near and almost total anoxia. Hypoxia reduces sensitivity to 5-fluorouracil (5-FU)-chemotherapy for colorectal cancer (CRC). MicroRNAs (miRNAs) are hypoxia sensors and were altered consistently in six CRC cell lines (colon cancer: DLD-1, HCT116 and HT...

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Udgivet i:Hum Mol Genet
Main Authors: Nijhuis, Anke, Thompson, Hannah, Adam, Julie, Parker, Alexandra, Gammon, Luke, Lewis, Amy, Bundy, Jacob G., Soga, Tomoyoshi, Jalaly, Aisha, Propper, David, Jeffery, Rosemary, Suraweera, Nirosha, McDonald, Sarah, Thaha, Mohamed A., Feakins, Roger, Lowe, Robert, Bishop, Cleo L., Silver, Andrew
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393147/
https://ncbi.nlm.nih.gov/pubmed/28207045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx059
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