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SMRT genome assembly corrects reference errors, resolving the genetic basis of virulence in Mycobacterium tuberculosis

BACKGROUND: The genetic basis of virulence in Mycobacterium tuberculosis has been investigated through genome comparisons of virulent (H37Rv) and attenuated (H37Ra) sister strains. Such analysis, however, relies heavily on the accuracy of the sequences. While the H37Rv reference genome has had sever...

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Detalhes bibliográficos
Publicado no:BMC Genomics
Main Authors: Elghraoui, Afif, Modlin, Samuel J., Valafar, Faramarz
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393005/
https://ncbi.nlm.nih.gov/pubmed/28415976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-3687-5
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