Low Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy

T cells with high functional avidity can sense and respond to low levels of cognate Ag, a characteristic that is associated with more potent responses against tumors and many infections, including HIV. Although an important determinant of T cell efficacy, it has proven difficult to selectively induc...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Billeskov, Rolf, Wang, Yichuan, Solaymani-Mohammadi, Shahram, Frey, Blake, Kulkarni, Shweta, Andersen, Peter, Agger, Else Marie, Sui, Yongjun, Berzofsky, Jay A.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2017
Assuntos:
Immunotherapy and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392729/
https://ncbi.nlm.nih.gov/pubmed/28348274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600965
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