SGLT2 Protein Expression Is Increased in Human Diabetic Nephropathy: SGLT2 PROTEIN INHIBITION DECREASES RENAL LIPID ACCUMULATION, INFLAMMATION, AND THE DEVELOPMENT OF NEPHROPATHY IN DIABETIC MICE

There is very limited human renal sodium gradient-dependent glucose transporter protein (SGLT2) mRNA and protein expression data reported in the literature. The first aim of this study was to determine SGLT2 mRNA and protein levels in human and animal models of diabetic nephropathy. We have found th...

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Vydáno v:J Biol Chem
Hlavní autoři: Wang, Xiaoxin X., Levi, Jonathan, Luo, Yuhuan, Myakala, Komuraiah, Herman-Edelstein, Michal, Qiu, Liru, Wang, Dong, Peng, Yingqiong, Grenz, Almut, Lucia, Scott, Dobrinskikh, Evgenia, D'Agati, Vivette D., Koepsell, Hermann, Kopp, Jeffrey B., Rosenberg, Avi Z., Levi, Moshe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392679/
https://ncbi.nlm.nih.gov/pubmed/28196866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.779520
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