Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4

Previous studies have shown that glucagon cooperatively interacts with insulin to stimulate hepatic FGF21 gene expression. Here we investigated the mechanism by which glucagon and insulin increased FGF21 gene transcription in primary hepatocyte cultures. Transfection analyses demonstrated that gluca...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Alonge, Kimberly M., Meares, Gordon P., Hillgartner, F. Bradley
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2017
Ämnen:
Gene Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392671/
https://ncbi.nlm.nih.gov/pubmed/28188284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762922
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