HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells

Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid peroxidation, although detailed molecular regulators are largely unknown. Here we show that heat shock 70kDa protein 5 (HSPA5) negatively regulates ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) ce...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Zhu, Shan, Zhang, Qiuhong, Sun, Xiaofan, Zeh, Herbert J., Lotze, Michael T., Kang, Rui, Tang, Daolin
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392369/
https://ncbi.nlm.nih.gov/pubmed/28130223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1979
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