Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles

The hypothesis that microvesicle (MV)-mediated microRNA transfer converts non-cancer stem cells into cancer stem cells (CSCs) leading to therapy resistance remains poorly investigated. Here we provide direct evidence supporting this hypothesis, by demonstrating how MV derived from cancer associated...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Sansone, Pasquale, Berishaj, Marjan, Rajasekhar, Vinagolu K., Ceccarelli, Claudio, Chang, Qing, Strillacci, Antonio, Savini, Claudia, Shapiro, Lauren, Bowman, Robert L., Mastroleo, Chiara, De Carolis, Sabrina, Daly, Laura, Benito-Martin, Alberto, Perna, Fabiana, Fabbri, Nicola, Healey, John H., Spisni, Enzo, Cricca, Monica, Lyden, David, Bonafé, Massimiliano, Bromberg, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392366/
https://ncbi.nlm.nih.gov/pubmed/28202520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2129
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