TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer

TP53 overexpression is indicative of somatic TP53 mutations and associates with aggressive tumors and poor prognosis in breast cancer. We utilized a two-stage SNP association study to detect variants associated with breast cancer survival in a TP53-dependent manner. Initially, a genome-wide study (n...

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書誌詳細
出版年:Oncotarget
主要な著者: Fagerholm, Rainer, Khan, Sofia, Schmidt, Marjanka K., GarcClosas, Montserrat, Heikkilä, Päivi, Saarela, Jani, Beesley, Jonathan, Jamshidi, Maral, Aittomäki, Kristiina, Liu, Jianjun, Raza Ali, H., Andrulis, Irene L., Beckmann, Matthias W., Behrens, Sabine, Blows, Fiona M., Brenner, Hermann, Chang-Claude, Jenny, Couch, Fergus J., Czene, Kamila, Fasching, Peter A., Figueroa, Jonine, Floris, Giuseppe, Glendon, Gord, Guo, Qi, Hall, Per, Hallberg, Emily, Hamann, Ute, Holleczek, Bernd, Hooning, Maartje J., Hopper, John L., Jager, Agnes, Kabisch, Maria, Investigators, kConFab/AOCS, Keeman, Renske, Kosma, Veli-Matti, Lambrechts, Diether, Lindblom, Annika, Mannermaa, Arto, Margolin, Sara, Provenzano, Elena, Shah, Mitul, Southey, Melissa C., Dennis, Joe, Lush, Michael, Michailidou, Kyriaki, Wang, Qin, Bolla, Manjeet K., Dunning, Alison M., Easton, Douglas F., Pharoah, Paul D.P ., Chenevix-Trench, Georgia, Blomqvist, Carl, Nevanlinna, Heli
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2017
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392336/
https://ncbi.nlm.nih.gov/pubmed/28179588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15110
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