Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients

INTRODUCTION: Somatic inactivation of the TP53 gene in breast tumors is a marker for poor outcome, and breast cancer outcome might also be affected by germ-line variation in the TP53 gene or its regulators. We investigated the effects of the germ-line single nucleotide polymorphisms TP53 R72P (215G&...

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Autori principali: Schmidt, Marjanka K, Tommiska, Johanna, Broeks, Annegien, van Leeuwen, Flora E, Van't Veer, Laura J, Pharoah, Paul DP, Easton, Douglas F, Shah, Mitul, Humphreys, Manjeet, Dörk, Thilo, Reincke, Scarlett A, Fagerholm, Rainer, Blomqvist, Carl, Nevanlinna, Heli
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
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Research article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815553/
https://ncbi.nlm.nih.gov/pubmed/20021639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2460
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