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Dynamics of a DNA Mismatch Site Held in Confinement Discriminate Epigenetic Modifications of Cytosine

The identification and discrimination of four epigenetic modifications to cytosine in the proposed active demethylation cycle is demonstrated at the single-molecule level, without the need for chemical pre-treatment or labeling. The wild-type protein nanopore α-hemolysin is used to capture individua...

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Bibliografski detalji
Izdano u:J Am Chem Soc
Glavni autori: Johnson, Robert P., Fleming, Aaron M., Perera, Rukshan T., Burrows, Cynthia J., White, Henry S.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392251/
https://ncbi.nlm.nih.gov/pubmed/28125225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b12284
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