Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS

Oligoclonal IgM bands restricted to cerebrospinal fluid are an unfavorable prognostic marker in MS, the most common demyelinating disease of the CNS. We have attempted to identify the B cell subpopulation responsible for oligoclonal IgM secretion and the specificity of these bands. In addition, we e...

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Autores principales: Villar, Luisa M., Sádaba, María C., Roldán, Ernesto, Masjuan, Jaime, González-Porqué, Pedro, Villarrubia, Noelia, Espiño, Mercedes, García-Trujillo, José A., Bootello, Alfredo, Álvarez-Cermeño, José C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC539201/
https://ncbi.nlm.nih.gov/pubmed/15630459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522833
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