Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS

Oligoclonal IgM bands restricted to cerebrospinal fluid are an unfavorable prognostic marker in MS, the most common demyelinating disease of the CNS. We have attempted to identify the B cell subpopulation responsible for oligoclonal IgM secretion and the specificity of these bands. In addition, we e...

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Detalhes bibliográficos
Main Authors: Villar, Luisa M., Sádaba, María C., Roldán, Ernesto, Masjuan, Jaime, González-Porqué, Pedro, Villarrubia, Noelia, Espiño, Mercedes, García-Trujillo, José A., Bootello, Alfredo, Álvarez-Cermeño, José C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC539201/
https://ncbi.nlm.nih.gov/pubmed/15630459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522833
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