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Is the canonical RAF-MEK-ERK signaling pathway a therapeutic target in SCLC?

The activity of the RAF-MEK-ERK signaling pathway is critical for the proliferation of normal and cancerous cells. Oncogenic mutations driving the development of lung adenocarcinoma often activate this signaling pathway. In contrast, pathway activity levels and their biological roles are not well es...

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Bibliografiske detaljer
Udgivet i:J Thorac Oncol
Main Authors: Cristea, Sandra, Sage, Julien
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391975/
https://ncbi.nlm.nih.gov/pubmed/27133774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2016.04.018
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