Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics

The ability of leukemia cells to accumulate methotrexate polyglutamate (MTXPG) is an important determinant of the antileukemic effects of methotrexate (MTX). We measured in vivo MTXPG accumulation in leukemia cells from 101 children with acute lymphoblastic leukemia (ALL) and established that B-line...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Kager, Leo, Cheok, Meyling, Yang, Wenjian, Zaza, Gianluigi, Cheng, Qing, Panetta, John C., Pui, Ching-Hon, Downing, James R., Relling, Mary V., Evans, William E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2005
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC539195/
https://ncbi.nlm.nih.gov/pubmed/15630450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522477
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items