Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics

The ability of leukemia cells to accumulate methotrexate polyglutamate (MTXPG) is an important determinant of the antileukemic effects of methotrexate (MTX). We measured in vivo MTXPG accumulation in leukemia cells from 101 children with acute lymphoblastic leukemia (ALL) and established that B-line...

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Main Authors: Kager, Leo, Cheok, Meyling, Yang, Wenjian, Zaza, Gianluigi, Cheng, Qing, Panetta, John C., Pui, Ching-Hon, Downing, James R., Relling, Mary V., Evans, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC539195/
https://ncbi.nlm.nih.gov/pubmed/15630450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522477
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