PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells

Altered regulation of insulin secretion by glucose is characteristic of individuals with type 2 diabetes mellitus, although the mechanisms that underlie this change remain unclear. We have now generated mice that lack the λ isoform of PKC in pancreatic β cells (βPKCλ(–/–) mice) and show that these a...

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Autors principals: Hashimoto, Naoko, Kido, Yoshiaki, Uchida, Tohru, Matsuda, Tomokazu, Suzuki, Kazuhisa, Inoue, Hiroshi, Matsumoto, Michihiro, Ogawa, Wataru, Maeda, Sakan, Fujihara, Hiroaki, Ueta, Yoichi, Uchiyama, Yasuo, Akimoto, Kazunori, Ohno, Shigeo, Noda, Tetsuo, Kasuga, Masato
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2005
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC539193/
https://ncbi.nlm.nih.gov/pubmed/15630453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522232
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