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The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway

Phosphoinositide-3 kinase (PI-3 kinase) and its downstream signaling molecules PDK-1 and Akt were analyzed in SK-N-SH and SK-N-BE(2) human neuroblastoma cell lines. When cells were stimulated with insulin, PI-3 kinase was activated in both cell lines, whereas the translocation of PDK-1 to the membra...

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Opis bibliograficzny
Główni autorzy: Seo, Ji Hae, Ahn, Younghee, Lee, Seung-Rock, Yeo, Chang Yeol, Hur, Kyu Chung
Format: Artigo
Język:Inglês
Wydane: The American Society for Cell Biology 2005
Hasła przedmiotowe:
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC539178/
https://ncbi.nlm.nih.gov/pubmed/15537704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-05-0369
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