Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17

We previously showed that the cell adhesion molecule Nectin-4 is overexpressed in ovarian cancer tumors, and its cleaved extracellular domain can be detected in the serum of ovarian cancer patients. The ADAM (a disintegrin and metalloproteinase) proteases are involved in ectodomain cleavage of trans...

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Опубликовано в: :J Biol Chem
Главные авторы: Buchanan, Petra C., Boylan, Kristin L. M., Walcheck, Bruce, Heinze, Rachel, Geller, Melissa A., Argenta, Peter A., Skubitz, Amy P. N.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2017
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391762/
https://ncbi.nlm.nih.gov/pubmed/28232483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.746859
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