Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch

The ligase Itch plays major roles in signaling pathways by inducing ubiquitylation-dependent degradation of several substrates. Substrate recognition and binding are critical for the regulation of this reaction. Like closely related ligases, Itch can interact with proteins containing a PPXY motif vi...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Desrochers, Guillaume, Cappadocia, Laurent, Lussier-Price, Mathieu, Ton, Anh-Tien, Ayoubi, Riham, Serohijos, Adrian, Omichinski, James G., Angers, Annie
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391761/
https://ncbi.nlm.nih.gov/pubmed/28235806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754440
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