Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid

mTOR, the mammalian target of rapamycin, integrates growth factor and nutrient signals to promote a transformation from catabolic to anabolic metabolism, cell growth, and cell cycle progression. Phosphatidic acid (PA) interacts with the FK506-binding protein–12-rapamycin-binding (FRB) domain of mTOR...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Menon, Deepak, Salloum, Darin, Bernfeld, Elyssa, Gorodetsky, Elizabeth, Akselrod, Alla, Frias, Maria A., Sudderth, Jessica, Chen, Pei-Hsuan, DeBerardinis, Ralph, Foster, David A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391759/
https://ncbi.nlm.nih.gov/pubmed/28223357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772988
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