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A stable but reversible integrated surrogate reporter for assaying CRISPR/Cas9-stimulated homology-directed repair

The discovery and application of CRISPR/Cas9 technology for genome editing has greatly accelerated targeted mutagenesis in a variety of organisms. CRISPR/Cas9-mediated site-specific cleavage is typically exploited for the generation of insertions or deletions (indels) after aberrant dsDNA repair via...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wen, Yahong, Liao, Grace, Pritchard, Thomas, Zhao, Ting-Ting, Connelly, Jon P., Pruett-Miller, Shondra M., Blanc, Valerie, Davidson, Nicholas O., Madison, Blair B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391747/
https://ncbi.nlm.nih.gov/pubmed/28228480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777722
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