Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties

Therapy with genetically modified autologous T cells has shown great promise in cancer therapy. For an efficient control of hepatitis C virus (HCV) infection, cytotoxic T cells (CTL) are pivotal, but persistence of activated T cells may lead to liver toxicity. Here, anti-HCV T cell receptors (TCRs)...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Balasiddaiah, Anangi, Davanian, Haleh, Aleman, Soo, Pasetto, Anna, Frelin, Lars, Sällberg, Matti, Lohmann, Volker, Koh, Sarene, Bertoletti, Antonio, Chen, Margaret
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391452/
https://ncbi.nlm.nih.gov/pubmed/28228595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00010-17
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