Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3

Hepatitis C virus (HCV) is a major cause of severe liver disease, and one major contributing factor is thought to involve a dysfunction of virus-specific T-cells. T-cell receptor (TCR) gene therapy with HCV-specific TCRs would increase the number of effector T-cells to promote virus clearance. We th...

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Main Authors: Pasetto, Anna, Frelin, Lars, Brass, Anette, Yasmeen, Anila, Koh, Sarene, Lohmann, Volker, Bartenschlager, Ralf, Magalhaes, Isabelle, Maeurer, Markus, Sällberg, Matti, Chen, Margaret
Formato: Artigo
Idioma:Inglês
Publicado: Society for General Microbiology 2012
Assuntos:
Animal
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352347/
https://ncbi.nlm.nih.gov/pubmed/22071510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.037903-0
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