Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate

Reduced p27 levels correlate with poor prognosis in a wide spectrum of human tumors and can accelerate tumorigenesis in mouse tissues. To determine whether p27 deficiency can accelerate tumorigenesis in tissues with inactive Rb and p53 pathways, we examined the effect of p27 status on prostate tumor...

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Detalhes bibliográficos
Main Authors: Shaffer, David R., Viale, Agnes, Ishiwata, Ryota, Leversha, Margaret, Olgac, Semra, Manova, Katia, Satagopan, Jaya, Scher, Howard, Koff, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC539141/
https://ncbi.nlm.nih.gov/pubmed/15615849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407362102
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