High-resolution respirometry of fine-needle muscle biopsies in pre-manifest Huntington’s disease expansion mutation carriers shows normal mitochondrial respiratory function

Alterations in mitochondrial respiration are an important hallmark of Huntington’s disease (HD), one of the most common monogenetic causes of neurodegeneration. The ubiquitous expression of the disease causing mutant huntingtin gene raises the prospect that mitochondrial respiratory deficits can be...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Buck, Eva, Zügel, Martina, Schumann, Uwe, Merz, Tamara, Gumpp, Anja M., Witting, Anke, Steinacker, Jürgen M., Landwehrmeyer, G. Bernhard, Weydt, Patrick, Calzia, Enrico, Lindenberg, Katrin S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390997/
https://ncbi.nlm.nih.gov/pubmed/28406926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175248
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