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Lysophosphatidic acid‐induced itch is mediated by signalling of LPA(5) receptor, phospholipase D and TRPA1/TRPV1
KEY POINTS: Lysophosphatidic acid (LPA) is an itch mediator, but not a pain mediator by a cheek injection model. Dorsal root ganglion neurons directly respond to LPA depending on transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1). LPA‐induced itch‐related behaviours are decreased...
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| Veröffentlicht in: | J Physiol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5390871/ https://ncbi.nlm.nih.gov/pubmed/28176353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273961 |
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