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Lysophosphatidic acid‐induced itch is mediated by signalling of LPA(5) receptor, phospholipase D and TRPA1/TRPV1

KEY POINTS: Lysophosphatidic acid (LPA) is an itch mediator, but not a pain mediator by a cheek injection model. Dorsal root ganglion neurons directly respond to LPA depending on transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1). LPA‐induced itch‐related behaviours are decreased...

詳細記述

保存先:
書誌詳細
出版年:J Physiol
主要な著者: Kittaka, Hiroki, Uchida, Kunitoshi, Fukuta, Naomi, Tominaga, Makoto
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390871/
https://ncbi.nlm.nih.gov/pubmed/28176353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273961
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