Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells

Thyroid cancer is a major component cancer of Cowden syndrome (CS), a disorder typically associated with germline mutations in PTEN. Germline variants in succinate dehydrogenase genes (SDHx) co-occurring with PTEN germline mutations confer a 2-fold increased prevalence (OR 2.7) of thyroid cancer com...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Yu, Wanfeng, Ni, Ying, Saji, Motoyasu, Ringel, Matthew D., Jaini, Ritika, Eng, Charis
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390680/
https://ncbi.nlm.nih.gov/pubmed/28164237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx037
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