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The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage
Overexpression of mutant p53 is a common finding in most cancers but testicular tumours accumulate wild-type p53 (wtp53). In contrast to the accepted concept that p53 homozygous mutant mice do not accumulate mutant p53 in normal cells, our study on a mutant p53 mouse model of Li-Fraumeni syndrome ha...
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| Udgivet i: | Oncogene |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5390101/ https://ncbi.nlm.nih.gov/pubmed/27869164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.374 |
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