Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans

Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously, we determined that decreased expression of the cyt...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Bennett, Christopher F., Kwon, Jane J., Chen, Christine, Russell, Joshua, Acosta, Kathlyn, Burnaevskiy, Nikolay, Crane, Matthew M., Bitto, Alessandro, Vander Wende, Helen, Simko, Marissa, Pineda, Victor, Rossner, Ryan, Wasko, Brian M., Choi, Haeri, Chen, Shiwen, Park, Shirley, Jafari, Gholamali, Sands, Bryan, Perez Olsen, Carissa, Mendenhall, Alexander R., Morgan, Philip G., Kaeberlein, Matt
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389855/
https://ncbi.nlm.nih.gov/pubmed/28355222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006695
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