Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans

Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously, we determined that decreased expression of the cyt...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Bennett, Christopher F., Kwon, Jane J., Chen, Christine, Russell, Joshua, Acosta, Kathlyn, Burnaevskiy, Nikolay, Crane, Matthew M., Bitto, Alessandro, Vander Wende, Helen, Simko, Marissa, Pineda, Victor, Rossner, Ryan, Wasko, Brian M., Choi, Haeri, Chen, Shiwen, Park, Shirley, Jafari, Gholamali, Sands, Bryan, Perez Olsen, Carissa, Mendenhall, Alexander R., Morgan, Philip G., Kaeberlein, Matt
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389855/
https://ncbi.nlm.nih.gov/pubmed/28355222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006695
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