Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription

The biogenesis of ribosomes in vivo is an essential process for cellular functions. Transcription of ribosomal RNA (rRNA) genes is the rate-limiting step in ribosome biogenesis controlled by environmental conditions. Here, we investigated the role of folate antagonist on changes of DNA double-strand...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Xie, Qiu, Li, Caihua, Song, Xiaozhen, Wu, Lihua, Jiang, Qian, Qiu, Zhiyong, Cao, Haiyan, Yu, Kaihui, Wan, Chunlei, Li, Jianting, Yang, Feng, Huang, Zebing, niu, Bo, Jiang, Zhengwen, Zhang, Ting
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389733/
https://ncbi.nlm.nih.gov/pubmed/27924000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1208
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