Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription

The biogenesis of ribosomes in vivo is an essential process for cellular functions. Transcription of ribosomal RNA (rRNA) genes is the rate-limiting step in ribosome biogenesis controlled by environmental conditions. Here, we investigated the role of folate antagonist on changes of DNA double-strand...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Xie, Qiu, Li, Caihua, Song, Xiaozhen, Wu, Lihua, Jiang, Qian, Qiu, Zhiyong, Cao, Haiyan, Yu, Kaihui, Wan, Chunlei, Li, Jianting, Yang, Feng, Huang, Zebing, niu, Bo, Jiang, Zhengwen, Zhang, Ting
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Gene regulation, Chromatin and Epigenetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389733/
https://ncbi.nlm.nih.gov/pubmed/27924000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1208
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