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Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization
The seven APOBEC3 (A3) enzymes in primates restrict HIV/SIV replication to differing degrees by deaminating cytosine in viral (−)DNA, which forms promutagenic uracils that inactivate the virus. A polymorphism in human APOBEC3C (A3C) that encodes an S188I mutation increases the enzymatic activity of...
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| Udgivet i: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389708/ https://ncbi.nlm.nih.gov/pubmed/28158858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx066 |
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