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Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B
The single-stranded DNA cytidine deaminases APOBEC3B, APOBEC3H haplotype I, and APOBEC3A can contribute to cancer through deamination of cytosine to form promutagenic uracil in genomic DNA. The enzymes must access single-stranded DNA during the dynamic processes of DNA replication or transcription,...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5714209/ https://ncbi.nlm.nih.gov/pubmed/28981865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx832 |
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