Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization

The seven APOBEC3 (A3) enzymes in primates restrict HIV/SIV replication to differing degrees by deaminating cytosine in viral (−)DNA, which forms promutagenic uracils that inactivate the virus. A polymorphism in human APOBEC3C (A3C) that encodes an S188I mutation increases the enzymatic activity of...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Adolph, Madison B., Ara, Anjuman, Feng, Yuqing, Wittkopp, Cristina J., Emerman, Michael, Fraser, James S., Chelico, Linda
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Nucleic Acid Enzymes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389708/
https://ncbi.nlm.nih.gov/pubmed/28158858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx066
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