Inhibiting translation elongation can aid genome duplication in Escherichia coli

Conflicts between replication and transcription challenge chromosome duplication. Escherichia coli replisome movement along transcribed DNA is promoted by Rep and UvrD accessory helicases with Δrep ΔuvrD cells being inviable under rapid growth conditions. We have discovered that mutations in a tRNA...

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Pubblicato in:Nucleic Acids Res
Autori principali: Myka, Kamila K., Hawkins, Michelle, Syeda, Aisha H., Gupta, Milind K., Meharg, Caroline, Dillingham, Mark S., Savery, Nigel J., Lloyd, Robert G., McGlynn, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389703/
https://ncbi.nlm.nih.gov/pubmed/27956500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1254
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