The homologous recombination protein RAD51D protects the genome from large deletions

Homologous recombination (HR) is a DNA double-strand break (DSB) repair pathway that protects the genome from chromosomal instability. RAD51 mediator proteins (i.e. paralogs) are critical for efficient HR in mammalian cells. However, how HR-deficient cells process DSBs is not clear. Here, we utilize...

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Udgivet i:Nucleic Acids Res
Main Authors: Reh, Wade A., Nairn, Rodney S., Lowery, Megan P., Vasquez, Karen M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389663/
https://ncbi.nlm.nih.gov/pubmed/27924006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1204
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