A structure–function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance

The sliding clamp, PCNA, plays a central role in DNA replication and repair. In the moving replication fork, PCNA is present at the leading strand and at each of the Okazaki fragments that are formed on the lagging strand. PCNA enhances the processivity of the replicative polymerases and provides a...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Shemesh, Keren, Sebesta, Marek, Pacesa, Martin, Sau, Soumitra, Bronstein, Alex, Parnas, Oren, Liefshitz, Batia, Venclovas, Česlovas, Krejci, Lumir, Kupiec, Martin
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389545/
https://ncbi.nlm.nih.gov/pubmed/28108661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1348
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